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Software Supply Chain Security (SSC) involves numerous stakeholders, processes and tools that work together to deliver a software product. A vulnerability in one element can cascade through the entire system and potentially affect thousands of dependents and millions of end users. Despite the SSC’s importance and the increasing awareness around its security, existing research mainly focuses on either technical aspects, exploring various attack vectors and their mitigation, or it empirically studies developers’ challenges, but mainly within the open source context. To better develop supportive tooling and education, we need to understand how developers consider and mitigate supply chain security challenges. We conducted 18 semi-structured interviews with experienced developers actively working in industry to gather in-depth insights into their experiences, encountered challenges, and the effectiveness of various strategies to secure the SSC. We find that the developers are generally interested in securing the supply chain, but encounter many obstacles in implementing effective security measures, both specific to SSC security and for general security. Developers also mention a wide set of approaches and methods to secure their projects, but mostly report general secure software engineering methodologies and seem to be mostly unaware of SSC specific threats and mitigations.